Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Summary

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Eligibility

Inclusion Criteria:

* Good general health, taking no medication on a chronic basis;
* age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
* BMI \>85th for obese cohort;

Exclusion Criteria:

* Baseline creatinine \>1.0 mg; pregnancy;
* the presence of endocrinopathies (e.g. Cushing syndrome);
* cardiac or pulmonary or other significant chronic illness;
* adolescents with a psychiatric disorder or with substance abuse;
* monogenic obesity syndromes;
* use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

Conditions2

Locations1 site

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