Effect of Vitamin D on Ovulation Rate in Women With Polycystic Ovary Syndrome

Summary

This is a randomized double-blind controlled trial on the effect of vitamin D supplementation to assess the ovulation rate of women with polycystic ovary syndrome (PCOS) and other reproductive, endocrine and metabolic outcomes after one year of treatment.

Eligibility

Inclusion Criteria:

* Premenopausal
* Aged 18-40 years
* Irregular long menstrual cycles (\>35 days)
* PCOS according to the Rotterdam criteria
* Agree for transvaginal ultrasound

Exclusion Criteria:

* Use of hormonal medication (including contraception) within 3 months prior to study inclusion, except the use of a progestogen to induce withdrawal bleeding every 3 months
* History of any medical condition or medications that may predispose to vitamin D sensitivity, altered vitamin D metabolism and/ or hypercalcemia, including active tuberculosis or current therapy for tuberculosis, sarcoidosis, history of renal/ ureteral stones, parathyroid disease, renal or liver failure or current use of anti-convulsants
* Use of insulin-sensitizing drugs, lipid lowering drugs or anti-hypertensive
* Anticipated to use the above medications in the coming one year
* Known type 2 diabetes mellitus
* Refusal to join the study
* Abnormal blood calcium level

For those on supplements, we asked them to stop their own supplements.

Conditions3

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