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Integrated Diagnostics for Early Diagnosis of Liver Disease

RECRUITINGSponsored by Manchester University NHS Foundation Trust
Actively Recruiting
SponsorManchester University NHS Foundation Trust
Started2020-10-21
Est. completion2027-03-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04666402

Summary

This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* All patients referred to Community Liver Assessment Clinic.
* Male or female \> 18 years of age.
* Females will be non-pregnant and non-lactating.

Exclusion Criteria:

* Age \< 18 years.
* Pregnancy/breast-feeding. Women of childbearing potential (not \>2 years post- menopausal and/or not surgically sterilised) must have a negative blood serum pregnancy test.
* Isolated bilirubinaemia.
* Known pre-existing liver disease.
* Acutely unwell.
* Suspected malignancy.

Conditions5

Alcoholic Liver DiseaseLiver DiseaseLiver FibrosesNon Alcoholic Fatty Liver DiseaseNon-Alcoholic Steatohepatitis

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