Role of Diet on the Microbiome of the Digestive System

Summary

This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.

Eligibility

Inclusion Criteria:

* GROUP I: Patients presenting for a screening colonoscopy

  * GROUP I: Age of 45 and above
  * GROUP I: Strict vegetarian diet, determined by using diet history questionnaire 3.0 National Institutes of Health (NIH)
  * GROUP I: Non smoker
  * GROUP I: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood samples
  * GROUP II: Patients presenting for a screening colonoscopy
  * GROUP II: Age of 45 and above
  * GROUP II: Omnivorous diet
  * GROUP II: Non smoker
  * GROUP II: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood sample

Exclusion Criteria:

* • Current smokers (nicotine abuse only)

  * Positive family history of colon cancer or colon cancer related syndromes
  * Recent use of antibiotics in 1 month
  * History of inflammatory bowel disease, and/or radiation enteritis or colitis
  * Pregnant and breastfeeding women
  * Women of child-bearing potential who have positive urine or serum pregnancy test
  * Heavy drinker (defined as more than 14 drinks per week)
  * Currently using anti-flatulence medications, probiotics and/or fiber supplements
  * Major dietary restrictions and/or following a special diet
  * Patient with positive fecal test/symptoms

Conditions2

Locations1 site

Browse More Trials