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iCorMicA - Stratified Medicine in Angina

RECRUITINGN/ASponsored by NHS Greater Glasgow and Clyde
Actively Recruiting
PhaseN/A
SponsorNHS Greater Glasgow and Clyde
Started2020-12-30
Est. completion2025-12-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04674449

Summary

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

1. Age ≥18 years.
2. A clinical plan for invasive coronary angiography.
3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
4. Able to comply with study procedures.
5. Able to provide informed consent.

Exclusion Criteria:

1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
2. History of coronary artery bypass surgery.
3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
4. Logistical reason\*. \*These patients will enter a follow-up registry.

Conditions11

Angina (Stable)Angina AttacksCoronary Artery DiseaseCoronary Microvascular Dysfunction (CMD)Coronary; IschemicHeart DiseaseIschaemic Heart DiseaseIschemia With No Obstructive Coronary Arteries (INOCA)Microvascular AnginaNon-Obstructive Coronary Atherosclerosis

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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