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A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

RECRUITINGSponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Actively Recruiting
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Started2020-11-24
Est. completion2026-11
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04677998

Summary

The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
* Age 18 years or older

Exclusion Criteria:

* Endoscopic removal of all polyps with an indication for removal not possible/feasible
* Gastric or duodenal cancer at baseline endoscopy
* Need for surgery

Conditions2

CancerFamilial Adenomatous Polyposis

Locations1 site

MD Anderson
Houston, Texas, 77030
Annie Lincoln+1 919 923 4430aglincoln@mdanderson.org

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