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A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

RECRUITINGSponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Actively Recruiting
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Started2021-11-24
Est. completion2026-11
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04678011

Summary

The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
* Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
* Age 18 years or older

Exclusion Criteria:

* Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
* Cancer at baseline endoscopy
* Need for surgery

Conditions2

CancerFamilial Adenomatous Polyposis

Locations1 site

MD Anderson
Houston, Texas, 77030
Annie Lincoln+1 919 923 4430aglincoln@mdanderson.org

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