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Pencil Beam Proton Therapy for Pelvic Recurrences in Rectal Cancer Patients Previously Treated With Radiotherapy

RECRUITINGPhase 2Sponsored by University of Aarhus
Actively Recruiting
PhasePhase 2
SponsorUniversity of Aarhus
Started2020-10-10
Est. completion2025-10-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04695782

Summary

Study design: A prospective phase II, non-randomized observational study of dose-escalated pencil beam proton therapy re-irradiation for pelvic recurrences from rectal cancer. Re-irradiation is either a part of neo-adjuvant treatment or as a definitive treatment strategy for un-resectable recurrences.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* • Locally recurrent rectal cancer.

  * Bioptically verified (adenocarcinoma )
  * Available dose plan from primary radiotherapy
  * Previous pelvic RT (\>30Gy EQD2)
  * Evaluated in MDT-conferences (Herlev, Aarhus)
  * Age\>18 years
  * PS 0-2
  * Adequate organ function
  * Informed consent

Exclusion Criteria:

* Non-resectable distant metastases (PET-CT)
* Unable to undergo MRI, PET-CT
* Inability to attend full course radiotherapy and follow up in the out patient clinic.

Conditions2

CancerRectal Cancer Recurrent

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