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Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

RECRUITINGN/ASponsored by Vanderbilt University Medical Center
Actively Recruiting
PhaseN/A
SponsorVanderbilt University Medical Center
Started2021-06-02
Est. completion2029-08
Eligibility
Age40 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04715984

Summary

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Eligibility

Age: 40 Years+Healthy volunteers accepted
Inclusion criteria:

* Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
* Planned clinical electrode trajectory that contacts caudate
* Age greater than or equal to 40
* Diagnosis of Parkinson's disease
* Able to participate in intraoperative testing
* English speaking

Exclusion criteria:

* Age less than 40
* Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
* Movement disorder other than Parkinson's disease

Conditions2

Parkinson DiseaseParkinson's Disease

Locations1 site

Vanderbilt University Medical Center
Nashville, Tennessee, 37212
Isabel Long, BS615-421-3046isabel.long@vumc.org

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