Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Summary

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.

Eligibility

Inclusion Criteria:

* Male or female patients
* 18 Years and older
* No history of atrial fibrillation
* CHA2DS2VASC score ≥3
* History pf type II diabetes
* History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease

Exclusion Criteria:

* History of atrial fibrillation
* Patients who had a clinically symptomatic acute stroke within the last 30-days
* Any health-related gadolinium/MRI contraindication (including previous allergic reaction to Gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
* Estimated glomerular filtration rate (eGFR) cutoff in patients with Chronic kidney disease (CKD) where gadolinium cannot be used equals an eGFR \<30 ml/min
* Weighing \> 300 lbs (as CMR image quality decreases due to increased body mass index)
* Current pregnancy or breastfeeding
* Cognitive impairment preventing the patient from giving an informed consent

Conditions7

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