Biobank for "Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment"

Summary

The 'ADAPT' Biobank is a collection of body material and data from patients with or at risk of cardiac arrhythmias who underwent or will undergo (non-) invasive treatment for this disease. Its main objective is to obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias, the multifactorial process, the heterogeneity in clinical presentation, and prognosis. Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

Eligibility

Inclusion criteria:

* Patients visiting the AMC outpatient clinic
* Patients included in an ongoing clinical trial linked to this biobank. Studies are listed under point "Groups and interventions" and include:

  * MARK AF
  * INDICO AF
  * PREDICT AF
  * WEIGHTLOSS AF
  * MAD AF
* Patients included in future clinical trial linked to this biobank. Studies may be linked to this biobank that investigates prevalent or incident cardiac arrhythmias.
* Cardiac arrhtymias are defined as

  * Supraventricular tachycardia, among which the most common are:

    * Atrial Fibrillation (AF)
    * Atrial Tachycardia (AT)
    * Atrial Flutter (AFL)
    * Atrioventricular Nodal Reentrant Tachycardia (AVNRT)
    * Atrioventricular Reentrant Tachycardia (AVRT)
  * Ventricular tachycardia, among which the most common are:

    * Ventricular Tachycardia (VT)
    * Ventricular Flutter (VFL)
    * Ventricular Fibrillation (VF)
  * Bradycardia:

    * Sinus Node Dysfunction
    * AV Node Dysfunction
    * Interventricular Conduction Disorder
  * Arrhythmogenic cardiomyopathies, among which the most common are:

    * Dilated Cardiomyopathy
    * Restrictive Cardiomyopathy
    * Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Exclusion criteria (shared for all studies):

* Age \< 18
* Unable or unwilling to comply with study procedures
* Pregnancy or of childbearing potential without adequate contraception
* NYHA class IV heart failure symptoms or left ventricular ejection fraction \<35%.

Conditions4

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