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Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

RECRUITINGN/ASponsored by University of Colorado, Denver
Actively Recruiting
PhaseN/A
SponsorUniversity of Colorado, Denver
Started2022-06-17
Est. completion2027-01-15
Eligibility
Age30 Years – 55 Years
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT04791371

Summary

The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.

Eligibility

Age: 30 Years – 55 YearsHealthy volunteers accepted
Inclusion Criteria:

* Sedentary (defined as less than 1 hour per week of physical activity)
* BMI: 25-40
* Men and women with and without type 2 diabetes

Exclusion Criteria:

* Documented cardiovascular disease
* Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
* Obstructive pulmonary disease or asthma
* Peripheral neuropathy
* Physical impairment that would limit exercise ability
* Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
* Current or past smoking within the last 1 years
* Current tobacco use
* Anemia
* Control HbA1c \> 5.7, T2DM HbA1c \> 9
* Pregnant, nursing or hormonal therapy (other than contraceptives)
* Peri or post-menopausal women
* Type 1 diabetes
* Hepatic or renal disease.

Conditions3

DiabetesOverweight and ObesityType 2 Diabetes

Locations2 sites

Colorado

1 site
University of Colorado
Aurora, Colorado, 80045
Benjamin Juckett, MS303-724-1338benjamin.juckett@cuanschutz.edu

Virginia

1 site
University of Virginia
Charlottesville, Virginia, 22908
Lee Hartline, MEd434-924-5247lmh9d@virginia.edu

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