Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD

Summary

The purpose of this study is to investigate the effects of exercise rehabilitation on cognition and to evaluate slow wave sleep (SWS) as a biomarker and mediator of response to rehabilitation-induced improvement in cognitive performance among persons with Parkinson's disease (PwP), with the ultimate goal of maximizing rehabilitation efficacy at the individual level (i.e. precision rehabilitation).

Eligibility

Inclusion:

* clinical diagnosis of idiopathic PD, based on the presence of bradykinesia as well as at least one of the following: rest tremor, rigidity, and/or postural instability (per United Kingdom PD Brain Bank Criteria)
* Hoehn and Yahr stage 2-3 (performed at screening visit)
* age ≥ 45 and
* on stable medications for at least 4 weeks prior to study entry without expecting to change medications for the duration of the study.
* Montreal Cognitive Assessment (MoCA) score ≥ 18 and \<26 (performed at screening visit)
* No contraindications to an exercise program.

Exclusion:

* fails exercise readiness evaluation at screening visit
* regular participation in an exercise program
* cardiovascular or pulmonary disease, including uncontrolled hypertension, congestive heart failure, unstable coronary artery disease, serious arrhythmia, stroke within the past year, or chronic obstructive pulmonary disease (COPD)
* shift workers
* signs indicative of atypical Parkinsonism (cerebellar signs, supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs)
* secondary Parkinsonism (neuroleptic treatment at time of onset of Parkinsonism or at time of study entry, history of multiple strokes with stepwise progression of Parkinsonism, or history of multiple head injuries)
* inability to walk without assistance
* deep brain stimulation (DBS)
* known narcolepsy
* untreated sleep apnea
* any condition that, in the opinion of the investigator, will preclude the participant from successfully or safely completing study procedures.

Conditions2

Locations1 site

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