MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Sclerosis

Summary

This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program

Eligibility

Inclusion Criteria for people with MS:

* Male/female patients aged 18 to 65 years at screening
* Diagnosis of MS according to the 2017 Revised McDonald criteria
* Disability status at screening with an EDSS score of 0 to 6.5
* Relapsing MS and progressive MS as defined by Lublin
* Neurologically stable within 1 month prior to screening
* Patients receiving the same Disease Modifying Treatment (DMT) for at least 6 months

Exclusion Criteria for people with MS:

* Patients suspected of not being able or willing to cooperate or comply with study protocol requirements
* Patients meeting criteria for other demyelinating diseases of the CNS
* Patients with active chronic disease (or stable but treated with immune therapy) of the immune system other than MS
* Patients with any other significant CNS disease or serious psychiatric disorder which can interfere with the patient's ability to cooperate or comply with the study procedure
* Patients unable or unwilling to undergo MRI scans and EEG

Inclusion Criteria for Healthy Controls:

• Normal hearing and normal or corrected-to-normal vision

Exclusion Criteria for Healthy Controls:

* Any diagnosed neurological, mental, developmental, or psychiatric disorder
* Unrecovered neurological disorders (i.e., stroke, traumatic brain injury)
* Unstable medication within the last 3 months
* Intake of central nervous drugs (e.g., antidepressants)
* Severe physical disorder
* Concurrent participation in another relevant study
* Patients unable or unwilling to undergo EEG measurements

Conditions2

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