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Exercise Effects on Adipose Tissue Structure and Function

RECRUITINGN/ASponsored by University of Michigan
Actively Recruiting
PhaseN/A
SponsorUniversity of Michigan
Started2021-03-01
Est. completion2026-03-01
Eligibility
Age18 Years – 40 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04812314

Summary

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

Eligibility

Age: 18 Years – 40 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age: 18-40
* Body Mass Index: 27-45 kg/m2
* No regularly planned exercise/physical activity for at least 6 months
* Women must have regularly occurring menses and must be premenopausal

Exclusion Criteria:

* Evidence/history of cardiovascular or metabolic disease
* Medications known to affect lipid or glucose metabolism, or inflammation
* Weight instability ≥ ± 6 pounds in the last 3 months
* Tobacco or e-cigarette users
* Women must not be pregnant or actively lactating

Conditions6

Insulin ResistanceMetabolic DiseaseMetabolic SyndromeObesityWeight GainWeight Loss

Locations1 site

University of Michigan
Ann Arbor, Michigan, 48109
Jeffrey F Horowitz7346471076jeffhoro@umich.edu

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