HyperSpectral Imaging in Low Grade Glioma

Summary

Low grade glioma (LGG) is a slowly evolving, highly invasive intrinsic brain tumor displaying only subtle tissue differences with the normal surrounding brain, hampering the attempts to visually discriminate tumor from normal brain, especially at the border interface. This makes anatomical borders hard to define during early maximal resection, which is the initial treatment strategy. Therefore, innovative, robust and easy-to-use real-time strategies for intra-operative detection and discrimination of (residual) LGG tumor tissue would strongly influence on-site, surgical decision making, enabling a maximal extent of resection. To validate this approach hyperspectral imaging (HSI) - using a SnapScan HSI-Camera (IMEC), stably mounted on an OPMI Pentero 900 microscope (Zeiss) - will be used to generate spectral imaging data patterns that discriminate in vivo low grade glioma tissue from normal brain both on the cortical and subcortical level.

Eligibility

Inclusion Criteria:

* Age ≥ 18 years
* Radiologically suspected low grade glioma (newly diagnosed or recurrent)
* Scheduled for tumor resection at UZ Leuven
* Signed informed consent document prior to resection

Exclusion Criteria:

* Children with age \< 18 years
* If final pathology reveals other pathological diagnosis than low grade glioma, datacubes will not be included in the final analysis

Conditions2

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