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Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

RECRUITINGPhase 2Sponsored by M.D. Anderson Cancer Center
Actively Recruiting
PhasePhase 2
SponsorM.D. Anderson Cancer Center
Started2021-05-26
Est. completion2026-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations7 sites

Summary

This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy. Oral stents are made from the impression of patients' mouth and cover patients' teeth and gums during radiation therapy. A customized, 3D-printed oral stent may help to reduce mouth blisters and/or sores that may develop in patients while receiving head and neck radiation therapy.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Participant is dispositioned to receive 5-7 weeks of definitive or adjuvant radiotherapy for treatment of a diagnosed head and neck malignancy
* Age 18 or older
* ECOG PS 0-2
* The participant will receive either (a) radiation alone or (b) radiation with concurrent chemotherapy of any kind(s)
* Signed study-specific consent form

Exclusion Criteria:

* Prior head and neck radiotherapy
* Participants is unable to fit a tongue-lateralizing or tongue-depressing stent
* Severe trismus with an incisal opening of \<10 mm
* Inability to comply with the study procedures
* Participants younger than 18 years of age
* Participants must not be pregnant
* Cognitively impaired subjects

Conditions8

CancerHead and Neck CarcinomaMalignant Parotid Gland NeoplasmMaxillary Sinus CarcinomaNasal Cavity CarcinomaOral Cavity CarcinomaTongue CarcinomaTonsillar Carcinoma

Locations7 sites

Banner Health/Banner Research
Phoenix, Arizona, 85234
Gary V. Walker, MD480-256-6444gary.walker@bannerhealth.com
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207
Mark E. Augspurger, MD904-202-7300mark.augspurger@bmcjax.com
Community MD Anderson Cancer Center East
Indianapolis, Indiana, 46219
Aleander Augustyn, MDaaugustyn@ecommunity.com
Community MD Anderson Cancer Center South
Indianapolis, Indiana, 46227
Alexander Augustyn, MDaaugustyn@ecommunity.com
Community MD Anderson Cancer Center North
Indianapolis, Indiana, 46250
Alexander Augustyn, MDaaugustyn@ecommunity.com

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