LT for Unresectable Colorectal Liver Metastasis

Summary

Unlike hepatocellular carcinoma, liver transplantation in patients with liver metastasis from colorectal cancer is limited in only few centers. Previously, it was not generally implemented due to lack of organs and high recurrence rates after transplantation. However, due to progressive development in treatments, good results such as increased survival rates can be expected even in liver transplant patients with liver metastasis from colorectal cancer, which is known to have poor prognosis. Therefore, the purpose of this study is to analyze the efficacy of liver transplantation as an alternative treatment for liver metastasis from colorectal cancer.

Eligibility

Inclusion Criteria:

* Proven colorectal cancer liver metastases without no other treatment (such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation)
* Metastasis isolated to liver
* Patients selected as a liver transplant recipient at a multidisciplinary meeting
* Paitents with a willing, healthy living donor
* Willing and able to provide written informed consent

Exclusion Criteria:

* Pregnant women
* Known history of human immunodeficiency virus (HIV) infection
* Patients with active peptic ulcer within 2 weeks of transplantation
* Persistent colorectal cancer after colon resection
* Hemodynamically unstable prior to liver transplantation
* Progression of LM at any timepoint prior to transplant surgery (assessed in a multidisciplinary meeting)

Conditions4

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