POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

Summary

To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.

Eligibility

Inclusion Criteria:

* All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study
* Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative

Exclusion Criteria:

This criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital.

* Patients who do not have the mental capacity to undergo the consent process
* For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).

Conditions5

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