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Angiotensin Receptor Blockers in Aortic Stenosis

RECRUITINGPhase 4Sponsored by Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Actively Recruiting
PhasePhase 4
SponsorInstitut universitaire de cardiologie et de pneumologie de Québec, University Laval
Started2020-02-01
Est. completion2027-02
Eligibility
Age20 Years – 99 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04913870

Summary

This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.

Eligibility

Age: 20 Years – 99 YearsHealthy volunteers accepted
Inclusion Criteria:

* Mild to moderate aortic stenosis (peak aortic jet velocity ≥2.5 and \<4m/s)
* Normal left ventricular ejection fraction (i.e. ≥50%)
* Systolic blood pressure \>110 mmHg
* Diastolic blood pressure \>70 mmHg

Exclusion Criteria:

* More than mild aortic or mitral regurgitation, or mitral stenosis
* Current use or documented indication for renin-angiotensin system medication or Aliskiren
* Known allergy or intolerance to angiotensin II receptor blockers (ARBs)
* Alzheimer, dementia or known non-compliant patient
* Renal dysfunction (glomerular filtration rate \<30ml/min/1.73m2)
* Chronic hyperkalemia
* Diagnosed hepatic failure, cirrhosis, hepatitis or history of hepatic impairment
* Newly diagnosed (\<2 months) or poorly controlled diabetes
* Pre-existing obstructive coronary artery disease with CCS III-IV angina or recent myocardial infarction (\<3 months)
* Pregnant or lactating women
* Patients unable to read, understand or sign research consent

Conditions3

Aortic StenosisAortic Valve StenosisHeart Disease

Interventions1

Angiotensin Receptor Blockers

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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