|

Natural History Study of Parathyroid Disorders

RECRUITINGSponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Actively Recruiting
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Started2021-11-30
Est. completion2031-01-22
Eligibility
Age6 Months – 100 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04969926

Summary

Background: Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling. PTH, the main secretory product of parathyroid glands is responsible for regulation of calcium-phosphate homeostasis. Objective: i) To investigate the cause of parathyroid disorders ii) To describe evolution, natural history, and longitudinal trends of parathyroid and related disorders seen in syndromic presentations like multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome Eligibility: People ages 6 months older who have, are at risk of having, or are related to a person with a parathyroid or related disorder. Design: Participants will be screened with a review of their medical records. Participants will be seen, tested, and treated by doctors based on their condition. Their visits may be in person or via telehealth. Participants will complete questionnaires. They will answer questions about their physical, mental, and social health. Participants may give samples such as saliva, blood, urine, or stool. Participants may give cheek cell samples. They will do this using a cheek swab or by spitting into a cup. Adult participants may give a skin biopsy. For this, a small bit of skin is removed with a punch tool. Participants may have medical photos taken. If participants have surgery during the course of their regular care either at the NIH or at a different hospital or doctor s office, researchers will ask for some of the leftover tissue. Participants will be in the study as long as they are being seen by their doctor.

Eligibility

Age: 6 Months – 100 YearsHealthy volunteers accepted
* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

* Subjects known to have, suspected of having, or at risk of developing a parathyroid or related disorder.
* Age \>= 6 months.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* Children \<= 6 months
* Patients with conditions that in the opinion of the investigators can interfere with the study objectives.

Conditions6

CancerInheritable Bone DiseasesMultiple Endocrine Neoplasia, Type 1Parathyroid CancerPrimary HyperparathyroidismPseudohypoparathyroidism

Locations1 site

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)800-411-1222ccopr@nih.gov

Browse More Trials

Cancer trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.