The Immune Responses After Hepatitis B Revaccination Doses in a Young Cohort

Summary

This prospective cohort study aims to provide the evidence-based clinical guide to help decide the revaccination doses of hepatitis B vaccine that the high-risk young adults without hepatitis B seroprotective antibodies (anti-HBs titer\<10 mIU/mL) need to take.

Eligibility

Inclusion Criteria:

1. The actual age at the time of admission was higher than 20 years old and birth year after 1987
2. Born in Taiwan and had received a full course of hepatitis B vaccines at least three doses at infant period.
3. Those who have tested negative for hepatitis B surface antibody and surface antigen at baseline
4. Have never been vaccinated against hepatitis B in childhood and adolescence by questionnaire
5. Consent to administer 1-2 doses of hepatitis B vaccine according to the assigned group after sharing decision making process
6. In good health

Exclusion Criteria:

1. Those who were previously allergic to hepatitis B vaccine or its components (such as yeast)
2. Those who have been vaccinated against hepatitis B during childhood and adolescence
3. Those who have a positive test for hepatitis B surface antibody or a positive test for hepatitis B surface antigen

Conditions4

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