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A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

RECRUITINGN/ASponsored by University of Rochester
Actively Recruiting
PhaseN/A
SponsorUniversity of Rochester
Started2022-01-03
Est. completion2026-06-30
Eligibility
Age60 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04981821

Summary

This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.

Eligibility

Age: 60 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥60 years (conventional definition of older age in clinical trials of MN)
* Have a diagnosis of MN
* Planned for or receiving outpatient cancer-directed treatments (participants receiving consolidative or maintenance outpatient therapies after induction chemotherapy are allowed to enroll)
* English speaking
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-3
* No medical contraindications for exercise per oncologist
* Able to walk 4 meters as part of Short Physical Performance Battery measured walk (with or without assistive device)
* Able to provide informed consent

Exclusion Criteria:

* Physical, psychological, or social impairments that would interfere with subject's ability to participate in the study or participate in the intervention, as determined by the PI or the treating team

Conditions2

CancerMyeloid Neoplasm

Locations1 site

University of Rochester Medical Center/Wilmot Cancer Institute
Rochester, New York, 14642
Kah Poh Loh, MBBCh BAO, MS

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