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Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study

RECRUITINGSponsored by Nottingham University Hospitals NHS Trust
Actively Recruiting
SponsorNottingham University Hospitals NHS Trust
Started2021-09-10
Est. completion2025-03
Eligibility
Age18 Years – 75 Years
View on ClinicalTrials.gov →

NCT04992975

Summary

A longitudinal observational neuroimaging study of individuals with Early Onset Alzheimer's disease during the prodromal phase, and matched control group - Ultrahigh Field MRI study at 7T

Eligibility

Age: 18 Years – 75 Years
Inclusion Criteria:

* Ability to provide informed consent
* Patients with pathological diagnosis of Alzheimer's disease according to the National Institute on Aging and Alzheimer's Association, NIA-AA, criteria (Alzheimer's group) or cognitively normal individuals within 1.5 standard deviation of normal in all tests (control group)

Exclusion Criteria:

* Lack of mental capacity to consent to study involvement
* Not speaking English before age 5 years
* Learning disability
* Schizophrenia
* Substance misuse
* Implanted devices not certified as compatible with ultra-high field MRI (e.g. cardiac pacemaker)
* Pregnancy

Conditions3

Alzheimer's DiseaseMild Cognitive ImpairmentProdromal Alzheimer's Disease

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