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A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients

RECRUITINGN/ASponsored by University of Greifswald
Actively Recruiting
PhaseN/A
SponsorUniversity of Greifswald
Started2021-12-01
Est. completion2024-07
Eligibility
Age20 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04996433

Summary

The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.

Eligibility

Age: 20 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x)
* Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20
* Treatment-resistance (TR) (defined as a level of 3 or higher on the Antidepressant Treatment History Form: Short Form (ATHF-SF) or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current episode)
* Sufficient knowledge of the German language
* Written informed consent

Exclusion Criteria:

* Bipolar I or II disorder
* Active substance use disorders (abstinence shorter than 6 months)
* Schizophrenia spectrum and other psychotic disorders
* Antisocial personality disorder
* Acute suicidality
* Previous CBASP or BA treatment within the last year
* Inability to tolerate CBASP or BA (e.g., organic brain disorders, severe cognitive deficits)
* Inability to participate in dayclinic or outpatient continuation treatment

Conditions3

DepressionPersistent Depressive DisorderTreatment-resistant Depression

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