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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

RECRUITINGSponsored by Petter Bjornstad
Actively Recruiting
SponsorPetter Bjornstad
Started2021-09-27
Est. completion2027-12-01
Eligibility
Age8 Years – 14 Years
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT05008276

Summary

Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.

Eligibility

Age: 8 Years – 14 YearsHealthy volunteers accepted
Inclusion Criteria:

* HbA1c ≥6.0% for untreated high-risk group
* BMI ≥ 85th %ile for high-risk group
* Normal HbA1c ≤5.6% for control group
* Type 1 diabetes (T1D) Antibody negative

Exclusion Criteria:

* History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
* Metabolic disorder prohibiting safe fasting
* Iodine or penicillin allergy
* Pregnancy
* Thrombophilia
* MRI contraindications
* Hormone therapy

Conditions7

Adolescent ObesityDiabetesDiabetic Kidney DiseaseKidney HypoxiaPre DiabetesPubertyType 2 Diabetes Mellitus

Locations2 sites

Colorado

1 site
Children's Hospital Colorado
Aurora, Colorado, 80045
Megan Kelsey, MD, MS720-777-0991Megan.Kelsey@childrenscolorado.org

Washington

1 site
Seattle Children's Hospital
Seattle, Washington, 98102
Petter M Bjornstad, MD(206) 616 3543pettermb@uw.edu

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