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A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

RECRUITINGPhase 2Sponsored by Memorial Sloan Kettering Cancer Center
Actively Recruiting
PhasePhase 2
SponsorMemorial Sloan Kettering Cancer Center
Started2021-08-11
Est. completion2027-08
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations7 sites
View on ClinicalTrials.gov →

NCT05010031

Summary

This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would still be effective to treat these tumors.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Histologically confirmed malignancy with at least one metastatic lesion referred for palliative radiotherapy
* Pathogenic mutation in ATM (somatic and germline allowed)
* ECOG performance status 0-2
* Age ≥ 18 years.
* Able to provide informed consent.
* Patients at reproductive potential must agree to practice an effective contraceptive method during radiation treatments.
* Expected life expectancy of at least 6 months

Exclusion Criteria:

* Previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances.
* Serious medical co-morbidities precluding radiotherapy.
* Pregnant or breast-feeding women.
* Lesions excluded from de-escalation include regions in which the risk of local disease progression is unacceptably high, including CNS disease and cord compression, and areas in which re-irradiation would not be feasible, including spinal cord overlap.

Conditions2

CancerMetastatic Cancer

Locations7 sites

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, 10065
Amy Xu, MD, PhD646-888-6863
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, 07748
Amy Xu, MD, PhD646-888-6863
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, 07645
Amy Xu, MD, PhD646-888-6863
Memorial Sloan Kettering Commack (All protocol activities)
Commack, New York, 11725
Amy Xu, MD, PhD646-888-6863
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, 10604
Amy Xu, MD, PhD646-888-6863

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