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Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy

RECRUITINGPhase 2Sponsored by Case Comprehensive Cancer Center
Actively Recruiting
PhasePhase 2
SponsorCase Comprehensive Cancer Center
Started2021-12-13
Est. completion2027-09
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05020912

Summary

The purpose of this study is to better understand the immune response to basal cell carcinoma (BCC) treated with Photodynamic Therapy (PDT) in order to develop new methods of treating BCC. Previous research suggests that PDT alters the immune response, possibly in a way that could promote better tumor clearance when combined with other treatments. Overall, participation in this study will help the study team better understand the anti-tumor immune response when BCC is treated with PDT.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adults scheduled to undergo Mohs surgery within the Dermatologic Surgery unit of the Department of Dermatology, Cleveland Clinic
* Must have at least one BCC tumor eligible for removal by surgical excision
* Men and women of any ethnic group are eligible
* Must provide informed consent to participate

Exclusion Criteria:

* Pregnant or breastfeeding
* Currently being treated for other cancers with medical or radiation therapy
* Known hypersensitivity to 5-aminolevulinic acid (ALA)
* History of a photosensitivity disease, e.g.,porphyria cutanea tarda

Conditions2

Basal Cell CarcinomaCancer

Locations1 site

Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, 44195
Edward V Maytin, MD, PhD216-444-5139maytine@ccf.org

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