Assessment of Quality of Life and Outcomes in Patients With Primary Renal Cell Carcinoma Treated With SBRT

Summary

This is a multicenter, single arm phase II study of stereotactic body radiation therapy (SBRT) for patients with medically inoperable primary renal cell carcinoma (RCC).

Eligibility

Inclusion Criteria:

* Patients ≥18 years old
* Newly diagnosed RCC by biopsy (preferred) or radiologic evidence of growth on surveillance over two consecutive assessments (6-12 months)
* Primary lesion \>3 cm, or recurrent lesion following local ablative therapy
* Medically inoperable or patient who refuses surgery following assessment by experienced urologist, and discussed in a multidisciplinary setting
* ECOG 0-2
* Written informed consent
* Participants must be able to understand the English-language or with the aid of a translator

Exclusion Criteria:

* Primary Lesion \>20cm
* Evidence of distant metastatic disease
* Previous abdominal RT in vicinity of kidney preventing definitive SBRT
* History of major radiosensitivity syndrome
* Second invasive malignancy within the past 3 years (excluding non-melanomatous skin cancer)
* Currently pregnant or lactating

Conditions2

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