13C-Glucose Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients.

Summary

The objective of the study is to investigate the metabolism of cells in the ascites tumour microenvironment of ovarian cancer patients. This observational study involves intravenous infusion of \[U-13C\]glucose into patients during standard paracentesis.

Eligibility

Inclusion Criteria:

* Ovarian cancer
* Any stage or grade of disease
* Ascites fluid that requires draining
* Any treatment regimen
* Primary or recurrent ascites
* Understands the concept of the study and give informed consent.

Exclusion Criteria:

* Participants must not have diabetes or abnormal hemoglobin A1C levels.
* The patient's glucose levels must be between 4 - 11.1 mM before administering an infusion. This is to ensure that patients are within normal blood glucose levels, as described by Diabetes Canada.
* Participants cannot receive chemotherapy treatment during the 5 hour duration of the experiment as it may compromise the integrity of the data.

Conditions3

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