UK Imaging Diabetes Study Seeing Diabetes Clearly

Summary

Prospective, observational cohort study to cross-sectionally assess the health of multiple organs, using multiparametric abdominal magnetic resonance imaging (MRI) scan, and understand if resulting MRI metrics can predict future clinical events over a period of 5 years, in adult patients with type 2 diabetes lacking history of cardiovascular disease.

Eligibility

Inclusion Criteria:

* Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy.
* Participant willing and able to give informed consent for participation in the study.

Exclusion Criteria:

In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of:

* myocardial infarction
* ischaemic stroke
* hospital admission/discharge for unstable angina
* heart surgery
* unstable angina
* transient ischemic attack
* The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MR exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
* Patients with known autoimmune hepatitis, viral hepatitis, Wilson's disease or known significant structural renal tract abnormality.
* Patients with known alcohol dependency.
* Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Conditions2

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