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A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia

RECRUITINGN/ASponsored by Gangnam Severance Hospital
Actively Recruiting
PhaseN/A
SponsorGangnam Severance Hospital
Started2021-12-16
Est. completion2026-07-31
Eligibility
Age19 Years – 80 Years
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05146778

Summary

In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.

Eligibility

Age: 19 Years – 80 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* All of patients will undergo mastectomy with or without immediate breast reconstruction.

Exclusion Criteria:

* Previous history of breast surgery
* Allergy to drug
* Other cancer history
* Underlying psychologic disorder
* Patients with chronic pain requiring pain killers
* Baseline SpO2 \<95%
* Left ventricular EF \<40%
* Bradycardia as HR \<50 bpm
* BMI \>35kg/m2
* Pregnant woman

Conditions5

Breast CancerCancerMastectomyPain, ChronicPain, Post Operative

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