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Sensory-Evoked Cortical Gamma Oscillation

RECRUITINGN/ASponsored by University of Tennessee Medical Center
Actively Recruiting
PhaseN/A
SponsorUniversity of Tennessee Medical Center
Started2022-07-01
Est. completion2025-12-31
Eligibility
Age60 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05206305

Summary

The purpose of the study is to investigate the efficacy of cortical gamma oscillation on visual sensory processing and cognitive function in Alzheimer's Disease (AD) patients by combining a therapeutic sensory stimulation device capable of evoking 40-Hz gamma oscillation via non-invasive visual and auditory stimulation with pre-established markers of cortical network activity, i.e., electroencephalography (EEG) and event-related potentials (ERP), to evaluate the applicability of the 40-Hz multimodel sensory stimulation as a novel therapeutic approach for treatment of AD patients.

Eligibility

Age: 60 Years+Healthy volunteers accepted
Inclusion Criteria:

* Individuals ages 60 and older with established diagnosis of Alzheimer's Disease as defined by the current consensus criteria for AD (Albert et al, 2011, Jack et al, 2011; McKhann et al, 2011)
* Fluent and literate in English language
* Able to consent for themselves based upon the MacArthur Competence Assessment Tool for Clinical Research
* Patients with a pre-existing positive A(beta)-PET and/or CSF tau/A(beta) markers or willingness to undergo a Lumbar Puncture (LP) with these results

Exclusion Criteria:

* Not fluent and literate in English
* Severe dementia
* Other medical conditions/neurodegenerative disease that could significantly impair cognitive abilities
* Cardiac pacemakers or any other implants that may not be compatible with MRI
* Cognitively impaired to the point the patient is unable to consent for themselves
* Claustrophobic to the point that medication is required

Conditions2

Alzheimer DiseaseAlzheimer's Disease

Locations1 site

University of Tennessee Medical Center
Knoxville, Tennessee, 37920
Janet H Parkey865-305-6194jparkey@utmck.edu

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