Lifestyle Patterns and Glycemic Control

Summary

The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose control, body composition, and liver fat. The results from this study has the potential to impact clinical practice and patient care.

Eligibility

Inclusion Criteria:

* Pre-diabetic kg/m2 (hemoglobin A1c 5.7-6.9%)
* 25 years or older
* BMI between 25-39.9 kg/m2
* Sleep duration ≥6 hours a night assessed with wrist actigraphy (for 14 nights)
* Variable bedtime, SD≥45 minutes.

Exclusion Criteria:

* Chronic Kidney Disease (GFR\<60)
* Uncontrolled hypertension (≥160/100 mmHg)
* Obstructive Sleep Apnea
* Psychiatric or neurological disorder
* Prevalent cardiovascular disease
* Dyslipidemia (triglycerides≥200 mg/dL)
* Medications that affect insulin sensitivity, glucose concentrations, and body weight
* Non-day or rotating shift workers
* Travel across time zones
* Active participation in weight loss program or within past 3 months
* Current or past alcohol/drug abuse

Conditions2

Locations1 site

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