Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique

Summary

In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .

Eligibility

Inclusion Criteria:

* Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique)
* Sporadic or familial form
* Informed with a written consent signed by the participant and the investigator
* Affiliate or beneficiary of french social security.

Exclusion Criteria:

* Patient who is not of African descent
* Refusal to participate.
* Patients not affiliated to french social security

Conditions2

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