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Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot

RECRUITINGN/ASponsored by Boston Children's Hospital
Actively Recruiting
PhaseN/A
SponsorBoston Children's Hospital
Started2022-11-04
Est. completion2023-11-03
Eligibility
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05236153

Summary

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of tetralogy of Fallot (TOF) or double outlet right ventricle (DORV)
* Referred for transcatheter pulmonary valve replacement (TPVR) per routine clinical indications
* Weight \>=25 kg

Conditions4

Heart DiseaseSudden Cardiac DeathTetralogy of FallotVentricular Tachycardia

Locations1 site

Boston Children's Hospital
Boston, Massachusetts, 02115
Edward T O'Leary, MD617-355-7833edward.oleary@cardio.chboston.org

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