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Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia

RECRUITINGSponsored by University Hospital, Clermont-Ferrand
Actively Recruiting
SponsorUniversity Hospital, Clermont-Ferrand
Started2022-03-07
Est. completion2027-03
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05246345

Summary

The purpose of this study is to collect medical informations and samples from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age greater than or equal to 18 years old;
* chronic lymphocytic leukemia diagnosis according to iwCLL criteria;
* refractory and/or relapsed disease during or after venetoclax treatment;
* tumor samples available.
* Relapse might be progressive chronic lymphocytic leukemia or transformation into Richter syndrome.
* Patients must be able to express their opposition to be enrolled in this study, if need be.
* Patients must be affiliated at the French Social Security system

Exclusion Criteria:

Patients of their legal guardians refusing to participate

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Conditions6

CLLCancerChronic Lymphocytic LeukemiaProgressive Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic LeukemiaRelapsed Chronic Lymphocytic Leukemia

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