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IV Acetaminophen After Cardiac Surgery - PILOT

RECRUITINGPhase 3Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre
Actively Recruiting
PhasePhase 3
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Started2023-06-06
Est. completion2024-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05246644

Summary

Double blind double dummy of Intravenous Acetaminophen and oral acetaminophen placebo versus IV placebo versus oral acetaminophen in patients following cardiac surgery. The primary endpoint is development of Delirium during the post-operative stay.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* subjects \> 18 years of age undergoing elective aortocoronary bypass, single valve replacement or single valve and aortocoronary bypass surgery

Exclusion Criteria:

* • Refusal by surgeon for inclusion of the patient

  * Requested late extubation by anesthesia or surgeon
  * Intra-aortic balloon pump
  * Sensitivity to acetaminophen
  * Pre-operative cognitive dysfunction
  * Psychiatric history with active treatment
  * Parkinson's disease
  * Alzheimer's disease
  * Medication for cognitive decline
  * History of recent seizures
  * Recent history of alcohol misuse
  * Creatinine clearance less than 30 ml/min

Conditions2

DeliriumHeart Disease

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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