|

The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults

RECRUITINGN/ASponsored by Boston Children's Hospital
Actively Recruiting
PhaseN/A
SponsorBoston Children's Hospital
Started2022-07-01
Est. completion2026-01
Eligibility
Age24 Years – 35 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05258981

Summary

The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).

Eligibility

Age: 24 Years – 35 YearsHealthy volunteers accepted
Inclusion Criteria:

* Persons who participated in the Boston circulatory arrest, pH and Hematocrit studies at Boston Childrens Hospital as children (n\~300).
* Normally-developed age- and sex-matched young adults who are able to provide informed consent to undergo the MRI portion of the study and limited neuropsychological evaluation (IQ assessment as well as neuropsychological tests for which normative references are not available).

Exclusion Criteria:

* For controls - inability to complete the MRI (implanted metal, claustrophobia, personal history of mental illness, brain injury, prior brain intervention).
* Intellectual impairment precluding completion of the study questionnaires independently
* Unable to speak and read English fluently

Conditions2

Congenital Heart DiseaseHeart Disease

Locations1 site

Boston Children's Hospital
Boston, Massachusetts, 02115
Michelle Gurvitz, MD617-355-6508michelle.gurvitz@cardio.chboston.org

Browse More Trials

Heart Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.