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Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries

RECRUITINGSponsored by Chonnam National University Hospital
Actively Recruiting
SponsorChonnam National University Hospital
Started2022-02-14
Est. completion2027-12-31
Eligibility
Age19 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05272618

Summary

To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.

Eligibility

Age: 19 Years+Healthy volunteers accepted
Inclusion Criteria:

* Subject with age ≥19 years and acute myocardial infarction

  * Rise and/or fall of cardiac troponin with one level \>99 percentile plus ischemic signs/symptoms

    * Subject with non-obstructive coronary arteries
  * \<50% diameter stenosis or
  * fractional flow reserve (FFR) \>0.80 ③ Subject without previous history of coronary artery disease

    * Subject who performed invasive coronary angiography within 24 hours after presentation ⑤ Subject who eligible for invasive and non-invasive coronary physiologic assessment

Exclusion Criteria:

* Subject with obstructive coronary arteries

  * Subject with alternate diagnosis including sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, and other cardiomyopathies.

    * Subject with cardiogenic shock or cardiac arrest ④ Subject who has non-cardiac co-morbid conditions with life expectancy \<1 year ⑤ Subject or lactating women ⑥ Subject unable to provide consent

Conditions4

Coronary Microvascular DysfunctionHeart DiseaseMyocardial InfarctionVasospasm, Coronary

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