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Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

RECRUITINGSponsored by University of Florida
Actively Recruiting
SponsorUniversity of Florida
Started2022-03-22
Est. completion2026-02-28
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05277025

Summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Ages 18-70
* Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
* Fulfills the 2010 ACR-EULAR classification criteria for RA
* Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion Criteria:

* Diabetes
* Cancer
* Advanced liver, kidney or cardiovascular disease
* Neuropathic pain

Conditions3

ArthritisFibromyalgiaRheumatoid Arthritis

Locations1 site

University of Florida
Gainesville, Florida, 32610
Melyssa Godfrey352-265-8901Melyssa.Godfrey@medicine.ufl.edu

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