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Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients

RECRUITINGN/ASponsored by Karolinska Institutet
Actively Recruiting
PhaseN/A
SponsorKarolinska Institutet
Started2022-05-18
Est. completion2025-10-31
Eligibility
Age18 Years – 50 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05277532

Summary

Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in a variety of insulin sensitive organs. The aim of this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensity interval training (HIIT) on glucose control and skeletal muscle metabolism in patients with overweight with or without type 1 diabetes (T1D).

Eligibility

Age: 18 Years – 50 YearsHealthy volunteers accepted
Inclusion Criteria:

* BMI 25-30
* type 1 diabetes or healthy subjects

Exclusion Criteria:

* nicotine usage,
* cardiovascular disease (CVD),
* blood pressure \>160/95,
* pregnancy,
* treatment with other pharmaceutical drugs than insulin, stable dose of thyroid hormone, statins, and antihypertensive drugs (excluding beta blockers).

Additional exclusion criteria for diabetes subjects:

* diabetes duration less than 6 months,
* proliferative or severe non-proliferative retinopathy,
* chronic kidney disease with glomerular filtration rate (GFR) \<60 ml/min,

Conditions3

DiabetesOverweightType 1 Diabetes

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