Neuroplasticity in Parkinson's Disease

Summary

The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions designed to prevent or slow disease progression.

Eligibility

Inclusion Criteria:

Participants with PD

* Diagnosis of idiopathic PD, as determined by a movement disorders neurologist in accordance with the PD Society Brain Bank diagnostic criteria
* Not receiving levodopa or dopamine agonist to treat PD (at baseline)
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters Healthy Controls
* Age- (+/- 3 years) and sex-matched to participants with PD
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters

Exclusion Criteria:

* Dementia diagnosis and/or a University of California Brief Assessment of Capacity to Consent (UBACC) score and MacCAT-CR score indicating impaired capacity to consent
* History of musculoskeletal disorders that significant affect movement of lower or upper limbs as determined at the time of enrollment
* History of bipolar disorder, post-traumatic stress disorder or major depressive disorder
* Other significant neurological disorders that may affect participation or performance in the study
* Implanted DBS or other neurosurgeries to treat PD
* Pregnancy

Additional exclusion criteria for TMS experiments (note that individuals who are excluded from the TMS experiment still have the opportunity to participate in the other data collection sessions):

* History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury
* Recent history of frequent syncope (fainting) episodes in response to blood, emotional stress, or sensory triggers.
* Intracranial metallic or magnetic devices (e.g. cochlear implant, deep brain stimulator)
* Pacemaker or any implanted device
* History of surgery on blood vessels, brain, or heart
* Unexplained, recurring headaches or concussion within the last six months
* Severe hearing impairment

Conditions3

Locations1 site

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