Fully Automated High-Throughput Quantitative MRI of the Liver

Summary

The purpose of this research is to see if a new automated magnetic resonance imaging (MRI) method will be able to improve the images taken of the liver. Participants will have either known or suspected liver disease, known or suspected iron overload syndrome, or be a healthy adult. Participants will be in the research study for one day.

Eligibility

Eligibility Criteria for Substudies 1, 2, 4, 5

Inclusion Criteria:

* Age 18 years or older

Exclusion Criteria:

* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)

Eligibility Criteria for Substudy 3

Inclusion Criteria:

* Age 7 years or older
* One of:

  * Known or suspected liver iron overload
  * Known or suspected elevated liver fat

Exclusion Criteria:

* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Sedation required for MRI
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)

Eligibility Criteria for Substudy 6

Inclusion Criteria:

* Age 7 years or older
* Scheduled for a clinical abdominal MRI exam

Exclusion Criteria:

* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Sedation required for MRI
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)

Conditions4

Locations1 site

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