Validation of the REMINDER Dementia Risk Reduction Program

Summary

Until now, neuropsychological interventions aimed to optimize cognitive function and to have functional impact in individuals at risk of AD (MCI patients) were scarce in validity studies. While some RCTs have been developed in cognitive training interventions, comparative studies of merged interventions (cognitive, social and behavioral stimulation) with adequate control groups are absent, diminishing the professionals' trust on the adoption of these interventions for supporting patients. As such, the present proposal will develop a validation trial testing a multicomponent neuropsychological intervention (REMINDER), based on personal development, cognitive compensatory aids, meaningful goals setting, and behavior change techniques. The investigators will analyze its short/long-term gains and AD conversion rates. By aiming to provide a good validation study for REMINDER, the investigators will examine neurobiological, neurocognitive and functional outcomes of this intervention in comparison with an active control group (psychoeducation) in order to foster an effective outcome assessment of an intervention for individuals at risk of AD.

Eligibility

Inclusion Criteria:

* Age 60 or older
* CAIDE dementia risk score \>8
* Cognitive function: absence of significant cognitive impairment as per the Addenbrooke's Cognitive Examination-REVISED
* Free of physical disabilities that preclude participation in the study
* Willing to complete all study-related activities for 12 weeks

Exclusion Criteria:

* Mild cognitive impairment or dementia;
* Presence of any neurological event in their medical history that could compromise actual cognition.
* Presence of any severe psychiatric disorder (mild depressive and anxiety symptoms meet inclusion criteria).
* Unability to travel to the site where the sessions will be delivered (if so randomization will be circumscribed between the experimental harm REMINDER online and the control group.
* Illiteracy

Conditions4

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