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Liver Cancer Disparities in American Indian and Alaska Native Persons

RECRUITINGPhase 2Sponsored by University of Washington
Actively Recruiting
PhasePhase 2
SponsorUniversity of Washington
Started2022-04-01
Est. completion2025-09-01
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05304234

Summary

We are performing a pilot and feasibility randomized controlled trial (RCT) of HCC screening by US + AFP every 6 months (n=100), the current standard-of-care, versus aMRI + AFP every 6 months (n=100) for 12 months (i.e. at time 0, 6 and 12 months) among AI/AN patients with cirrhosis or HBV.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Cirrhosis, any etiology, or chronic HBV infection
* High risk of HCC
* Age 18-75
* Competent to provide informed consent

Exclusion Criteria:

* Prior diagnosis of HCC
* Current suspicion of HCC
* Prior receipt of any organ transplantation
* Participation in another HCC screening trial
* CTP score \>=10
* MELD-Na score \>20
* GFR\<30
* Poor life expectancy (\<5 years)
* Contraindication to MRI
* Inability to complete study visits
* Currently pregnant

Conditions6

CancerCirrhosis, LiverHepatitis BHepatocellular CarcinomaLiver CancerLiver Disease

Locations1 site

Cherokee Nation Health Service
Tahlequah, Oklahoma, 74464
Jorge Mera

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