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Cytokine Expression in Psoriasis Patients with and Without Joint Involvement

RECRUITINGN/ASponsored by Poitiers University Hospital
Actively Recruiting
PhaseN/A
SponsorPoitiers University Hospital
Started2022-08-17
Est. completion2026-08-17
Eligibility
Age18 Years – 100 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05307809

Summary

The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.

Eligibility

Age: 18 Years – 100 YearsHealthy volunteers accepted
Inclusion criteria:

* For psoriasis patients :

  * Age over 18 years old
  * Signed informed consent
  * 5 year old psoriasis at least
  * At least one skin lesion over 2 cm
  * Without any articular symptoms
  * Without any DMARDs
  * Without anticoagulant treatments or coagulation disease
  * With normal articular and enthesis sonography
* For psoriatic arthritis patients :

  * Age over 18 years old
  * Signed informed consent
  * Psoriatic arthritis according to CASPAR criteria
  * Without any DMARDs
  * Without anticoagulant treatments or coagulation disease
  * With at least one synovitis at inclusion
* For controls

  * Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
  * No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old

Exclusion criteria:

▪ For psoriasis patients :

* Joint damage according to CASPAR criteria
* Echography activity in favor of chronic inflammatory rheumatism
* For patients and controls:
* Without social protection rights
* People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.

Conditions3

ArthritisPsoriasisPsoriatic Arthritis

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