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Surgery or Chemoradiotherapy for Cervical Esophageal Cancer

RECRUITINGN/ASponsored by Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Actively Recruiting
PhaseN/A
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
Started2022-04-10
Est. completion2028-12-31
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05327517

Summary

To compare surgery with definitive chemoradiotherapy for patients with resectable cervical esophageal squamous cell carcinoma.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients with resectable cervical esophageal squamous cell carcinoma (cT1b-T4aN0-3M0);
* Cervical esophageal cancers spreads upwards to involve the hypopharynx and downwards to involve the thoracic esophagus can also be included;
* Aged 18-75 years;
* Without any contraindication of operation;
* Hemoglobin \>=90 g/L; Leukocytes \>=4.0x10\^9/L; Absolute neutrophil count \>=1.5x10\^9/L; Platelet \>=100x10\^9/L;Total bilirubin \<=1.5 ULN; ALT \<=2.5 ULN; AST \<=2.5 ULN; Serum creatinine \<=1.5 ULN or creatinine clearance rate \>=50 mL/min (Cocheroft-Gault);INR \<=1.5 ULN; APTT \<=1.5 ULN;
* Without other malignancies;
* Expected R0 resection;
* ECOG PS 0-1;
* Volunteered to participate in the study, signed the informed consent form.

Exclusion Criteria:

* Without other malignancies;
* With mental diseases;
* With hemorrhagic disease;
* Inoperable patients;
* Pregnant or lactating women;
* Has a history of allergy to paclitaxel or cisplatin

Conditions2

CancerCervical Esophageal Cancer

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