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The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation

RECRUITINGN/ASponsored by National Taiwan University Hospital
Actively Recruiting
PhaseN/A
SponsorNational Taiwan University Hospital
Started2025-07-01
Est. completion2025-07-31
Eligibility
Age20 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05332457

Summary

This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).

Eligibility

Age: 20 Years+Healthy volunteers accepted
Inclusion Criteria:

1. \> 20 years of age.
2. Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months.
3. Resting heart rate \< 80 bpm.
4. Left ventricular ejection fraction \> 50%.

Exclusion Criteria:

1. Beta-blocker usage due to indications other than rate control for atrial fibrillation.
2. Inability to perform a cardiopulmonary exercise testing.
3. Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription.
4. Patients with implantable cardioverter defibrillator or pacemaker.
5. Pregnancy.
6. Inability to provide informed consent.

Conditions2

Atrial FibrillationHeart Disease

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