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Optimizing Pulsatility During Cardiopulmonary Bypass

RECRUITINGSponsored by University of Colorado, Denver
Actively Recruiting
SponsorUniversity of Colorado, Denver
Started2022-07-05
Est. completion2024-12-01
Eligibility
Age50 Years – 70 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05344573

Summary

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Eligibility

Age: 50 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age 50 to 70
* Able to provide informed consent
* Scheduled for elective cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

* Patients undergoing emergency procedures
* Diagnosed with sepsis
* Experiencing delirium
* Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
* Patients with a mechanical circulatory support device
* Requiring vasoactive medications before surgery
* Patients with a reduced left ventricular ejection fraction (less than 50%)
* Patients with a contraindication to transesophageal echocardiography

Conditions3

Acute Kidney InjuryEndothelial DysfunctionHeart Disease

Locations1 site

University of Colorado Hospital
Aurora, Colorado, 80045
Nathan Clendenen, MD MS303-724-5000nathan.clendenen@cuanschutz.edu

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